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Scientists unlock secret of death protein’s activationNovember 28

Scientists at Dana-Farber Cancer Institute have identified a previously undetected trigger point on a naturally occurring “death protein” that helps the body get rid of unwanted or diseased cells. They say it may be possible to exploit the newly found trigger as a target for designer drugs that would treat cancer by forcing malignant cells to commit suicide.

Loren Walensky, MD, PhD, pediatric oncologist and chemical biologist at Dana-Farber and Children’s Hospital Boston, and colleagues report in the Oct. 23 issue of the journal Nature that they directly activated this trigger on the “executioner” protein BAX, killing laboratory cells by setting in motion their self-destruct mechanism.

The researchers fashioned a peptide (a protein subunit) that precisely matched the shape of the newly found trigger site on the killer protein, which lies dormant in the cell’s interior until activated by cellular stress. When the peptide docked into the binding site, BAX was spurred into assassin mode. The activated BAX proteins flocked to the cell’s power plants, the mitochondria, where they poked holes in the mitochondria’s membranes, killing the cells. This process is called apoptosis, or programmed cell death.

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University researchers developing cancer-fighting beerNovember 25

Have you ever picked up a cold, frosty beer on a hot summer’s day and thought that it simply couldn’t get any better?

Well, you may have to think again.

A team of researchers at Rice University in Houston is working to create a beer that could fight cancer and heart disease. Taylor Stevenson, a member of the six-student research team and a junior at Rice, said the team is using genetic engineering to create a beer that includes resveratrol, the disease-fighting chemical that’s been found in red wine.

Scientists at the University of Wisconsin in June had called resveratrol, which is a natural component of grapes, pomegranates and red wine, a key reason for the so-called French Paradox — the observation that French people have lower rates of heart disease despite a cuisine known for its cream sauces and decadent cheeses, all loaded with heart-clogging saturated fats.

The Wisconsin researchers had noted that adding small doses of resveratrol to the diet of middle-aged mice significantly slows their aging and keeps their hearts healthy. And they added that giving high doses to invertebrates extends their life spans, and high doses also stave off premature death in mice fed a high-fat diet.

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MIT Energy Storage Discovery Could Lead to ‘Unlimited’ Solar PowerNovember 23

Researchers at Massachusetts Institute of Technology (MIT) have discovered a new way of storing energy from sunlight that could lead to ‘unlimited’ solar power.

The process, loosely based on plant photosynthesis, uses solar energy to split water into hydrogen and oxygen gases. When needed, the gases can then be re-combined in a fuel cell, creating carbon-free electricity whether the sun is shining or not.

According to project leader Prof. Daniel Nocera, “This is the nirvana of what we’ve been talking about for years. Solar power has always been a limited, far-off solution. Now, we can seriously think about solar power as unlimited and soon.”

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3D Printers Now as Cheap As Laser Printers Were in 1985November 20

We do go on about the possibilities of downloadable designs, where you can pick the best from around the world and get it printed up at some form of 3D Kinko that might some day be in every neighbourhood.

Perhaps that vision isn’t wild enough; the Ponoko blog notes that the desktop publishing revolution was born when the Apple LaserWriter was released in 1985 for $6995. Now Desktop Factory is launching a 3D printer that isn’t much bigger than that laser printer, and at $5,000 in 2008 dollars a whole lot cheaper.

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NVIDIA Graphics Card Renders Realistic Human Head in Real-TimeNovember 19

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